Nickel-catalyzed triarylamine synthesis: synthetic and mechanistic aspects.

نویسندگان

  • Xin-Le Li
  • Wei Wu
  • Xin-Heng Fan
  • Lian-Ming Yang
چکیده

An improved protocol was described for the amination of chloroarenes with diarylamines under NiCl2(PCy3)2 catalysis in the presence of a Grignard reagent as base. This method fully suits bromo-/iodoarene substrates as well, and even is expanded to certain aryl tosylates. A preliminary investigation into the mechanism suggests that this amination reaction might proceed through Ni(I) and Ni(III) intermediates rather than via the usually expected Ni(0)-Ni(II) cycle.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 12 8  شماره 

صفحات  -

تاریخ انتشار 2014